#08054: Glycan Markers of Hepatocellular Carcinoma

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TECH FIELD(S)
Medical Biomarkers
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FEATURES
Hepatocellular Carcinoma (HCC) is a worldwide health problem. Serum alpha-fetoprotein, the current marker for HCC, is not effective for early diagnosis. It would be advantageous to develop markers for early detection of HCC. The inventors employed MALDI-TOF mass spectrometry for analysis of N-glycans in patient serum samples. The N-glycan analysis was performed by the solid phase permethylation technique described in IURTC Tech ID No. 05061.
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BENEFITS
A set of three N-glycans was identified that is sufficient for detection of HCC.

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INVENTOR(S)

Milos V. Novotny, Ph.D.-Indiana University, Department of Chemistry

Yehia Mechref, Ph.D.- Indiana University, Department of Chemistry

Radoslav Goldman, Ph.D. - Georgetown University , Lombardi Comprehensive Cancer Center

Habtom W. Ressom, Ph.D. - Georgetown University , Lombardi Comprehensive Cancer Center

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INTELLECTUAL PROPERTY STATUS
US provisional patent application pending.
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CONTACT INFORMATION
For additional information on this technology, please contact Bill Brizzard, Director of Technology Transfer, IURTC:

Indiana University Research & Technology Corporation
501 North Morton Street, Suite 204
Bloomington, IN 47404
Telephone:812-855-3597
bbrizzar@iu.edu

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